彭敏實驗室長期致力于T細胞的基礎(chǔ)和應(yīng)用研究,探索T細胞激活、增殖、分化、代謝、記憶和耗竭等關(guān)鍵過程的調(diào)控機制,發(fā)展T細胞研究和改造的前沿技術(shù),開發(fā)全新的T細胞療法,實現(xiàn)對常見重大疾病的治療和治愈。
彭敏2005獲得四川大學(xué)華西醫(yī)學(xué)院臨床醫(yī)學(xué)學(xué)士學(xué)位,2010年獲得北京協(xié)和醫(yī)學(xué)院免疫學(xué)博士學(xué)位。2010~2017年,彭敏在紐約紀(jì)念斯隆凱特琳癌癥中心(MSKCC)
博士后(2名):T細胞基礎(chǔ)和應(yīng)用研究
應(yīng)聘條件:符合清
工作待遇:博士后崗位待遇按照清華大學(xué)相關(guān)規(guī)定執(zhí)行。積極支持條件優(yōu)秀者申請國家“博新計劃”、清華大學(xué)“水木學(xué)者”計劃(http://postdoctor.tsinghua.edu.cn/thu/index.htm)、生命科學(xué)聯(lián)合中心博士后基金、以及其他多種清
科研助理(1名):輔助開展課題以及實驗室日常管理
應(yīng)聘條件:已獲得或即將獲得免疫學(xué)、基礎(chǔ)醫(yī)學(xué)、生物化學(xué)和細胞生物學(xué)等相關(guān)專業(yè)本科學(xué)位;對科學(xué)研究有興趣,誠信、有責(zé)任心、做事有條理、具備團隊合作精神。
申請方式:提供詳細簡歷(含學(xué)習(xí)、工作經(jīng)歷、發(fā)表文章、研究興趣、研究成果以及未來職業(yè)規(guī)劃等),博士后提供1-2名推薦人(含博士生導(dǎo)師)的聯(lián)系方式,發(fā)至:(點擊查看),請【點擊下方“立即投遞/投遞簡歷”,即刻進行職位報名】;主題標(biāo)明“姓名+
彭敏實驗室近期發(fā)表文章:
1.Gang Jin, Yanyan Liu, Lixia Wang, Zihao He, Xiaocui Zhao, Yuying Ma, Yuting Jia, Zhuoyang Li, Na Yin, Min Peng*. A single infusion of engineered long-lived and multifunctional T cells confers durable remission of asthma in mice. Nat Immunol. 2024. Jun;25(6):1059-1072. Previewed by Bart Lambrecht and Hamida Hammad in Nat Immunol, “CAR T cells put the brakes on asthma”. Highlighted by Yvonne Bordon in Nat Rev Immunol and Nat Rev Drug Discov, “CAR T cells take to the airways”.
2.Lixia Wang, Gang Jin, Qiuping Zhou, Yanyan Liu, Xiaocui Zhao, Zhuoyang Li, Na Yin, Min Peng*. Induction of immortal-like and functional CAR T cells by defined factors. J Exp Med. 2024 May 6;221(5):e20232368. Previewed by Nicholas Restifo and Luca Gattinoni in J Exp Med, “Synthetic soldiers: Turning T cells into immortal warriors”.
3.Ying Liu, Yuying Ma, Jing Xu, Guangyue Zhang, Xiaocui Zhao, Zihao He, Lixia Wang, Na Yin, Min Peng*. VMP1 prevents Ca2+ overload in endoplasmic reticulum and maintains naive T cell survival. J Exp Med. 2023 Jun 5;220(6):e20221068.
4.Min Peng*, Ming O. Li*. Metabolism along the life journey of T cells. Life Metabolism. 2023, 002(001)
5.Na Yin, Gang Jin, Yuying Ma, Hanfei Zhao, Guangyue Zhang, Ming O. Li, Min Peng*. SZT2 maintains hematopoietic stem cell homeostasis via nutrient-mediated mTORC1 regulation. J Clin Invest., 2022 Oct 17, 130(20):e146272.
6.Hanfei Zhao, Ying Liu, Lixia Wang, Gang Jin, Xiaocui Zhao, Jing Xu, Guangyue Zhang, Yuying Ma, Na Yin, Min Peng*. Genome-wide fitness gene identification reveals Roquin as a potent suppressor of CD8 T cell expansion and anti-tumor immunity. Cell Reports. 2021 Dec 7;37(10):110083.
1. Min Peng, Na Yin, Ming O. Li. SZT2 dictates GATOR control of mTORC1 signaling. Nature. 2017 Mar 16;543(7645):433-437.
2. Min Peng, Na Yin, Sagar Chhangawala, Ke Xu, Christina S. Leslie, Ming O. Li. Aerobic glycolysis promotes T helper 1 cell differentiation through an epigenetic mechanism. Science, 2016 Oct 28; 354(6311): 481-484. Preview in Science, 2016 Oct 28; 354(6311): 419-420. “Warburg meets epigenetics”. Preview in Dev Cell, 2016 November 7;39: 286-287. “Metabolic Control of Cellular Differentiation”. Preview in Cell Metab, 2016 November 8; 24: 651-652. “Metabolic Signaling Drives IFN-g”.
3. Min Peng, Na Yin, Ming O. Li. Sestrins Function as Guanine Nucleotide Dissociation Inhibitors for Rag GTPases to Control mTORC1 Signaling. Cell. 2014 Sep 25; 159(1): 122-33. Highlighted in Nat Rev Mol Cell Biol, 2014; 15: 701, “A RAG dissociation inhibitor”.
信息來源于網(wǎng)絡(luò),如有變更請以原發(fā)布者為準(zhǔn)。
來源鏈接:
http://www.cls.edu.cn/info/1278/5003.htm
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