一、單位簡介
首都醫(yī)學(xué)科學(xué)創(chuàng)新中心（簡稱創(chuàng)新中心）是北京市新成立的具有獨(dú)立法人資格的新型研發(fā)機(jī)構(gòu)。創(chuàng)新中心以推動醫(yī)學(xué)科學(xué)發(fā)展、改善人類健康為目標(biāo)，開展生物醫(yī)學(xué)研究，致力于提升醫(yī)學(xué)科學(xué)創(chuàng)新與成果轉(zhuǎn)化能力，提高疾病診斷和治療水平。我們將匯聚世界高水平科學(xué)家，與首都醫(yī)學(xué)教育和科學(xué)研究優(yōu)質(zhì)資源緊密合作，打造多學(xué)科交叉融合的科研平臺，綜合自由探索、醫(yī)學(xué)目標(biāo)導(dǎo)向、有組織科研等途徑，實(shí)踐新型科研模式和體制機(jī)制，逐步推進(jìn)醫(yī)教研產(chǎn)的深度融合，培養(yǎng)適應(yīng)醫(yī)學(xué)科學(xué)創(chuàng)新發(fā)展的優(yōu)秀人才。
01實(shí)驗(yàn)室介紹
鄧慶實(shí)驗(yàn)室現(xiàn)面向國內(nèi)外招聘博士后與科研助理，實(shí)驗(yàn)室將利用深度免疫分型、單細(xì)胞及空間多組學(xué)平臺、細(xì)胞分子生物學(xué)技術(shù)和遺傳動物模型，解析B細(xì)胞異質(zhì)性與腫瘤發(fā)展、轉(zhuǎn)移以及免疫治療效果的關(guān)聯(lián)性，深入理解B細(xì)胞在腫瘤及自身免疫性疾病中的免疫調(diào)控機(jī)制，并進(jìn)一步探索靶向干預(yù)B細(xì)胞成熟命運(yùn)途徑的潛在治療策略。鄧慶研究員本科畢業(yè)于蘇州大學(xué)生命科學(xué)學(xué)院，在上海交通大學(xué)醫(yī)學(xué)院獲得博士學(xué)位。先后在上海人類基因組研究中心、貝勒醫(yī)學(xué)院以及德克薩斯大學(xué)MD安德森癌癥中心等國內(nèi)外知名科研機(jī)構(gòu)進(jìn)行博士后研究工作，現(xiàn)為首都醫(yī)學(xué)科學(xué)創(chuàng)新中心（CIMR）研究員。
02主要研究方向
腫瘤微環(huán)境中B淋巴細(xì)胞以及三級淋巴結(jié)構(gòu)的特征分析，深入理解B細(xì)胞命運(yùn)調(diào)控的分子生物學(xué)事件在腫瘤、自身免疫性疾病中的病理機(jī)制并提供潛在的治療策略。
1. 調(diào)控腫瘤浸潤B細(xì)胞生發(fā)中心依賴/非依賴型應(yīng)答的關(guān)鍵分子機(jī)制與網(wǎng)絡(luò)。
2. 三級淋巴結(jié)構(gòu)中B細(xì)胞發(fā)育與篩選的機(jī)制。
3. 鑒定B細(xì)胞命運(yùn)重塑的分子靶點(diǎn)。
03研究成果與代表性論文
1. 揭示SWI/SNF染色質(zhì)重塑復(fù)合物基因突變及其調(diào)控腫瘤細(xì)胞惡性特征、命運(yùn)決定的分子機(jī)制（Cancer Cell 2024, PMID: 38458188 & PMID: 38458187; Nature Genetics 2012, PMID: 22922871）。
2. 揭示CD19 CAR-T細(xì)胞與B細(xì)胞淋巴瘤治療療效和毒性相關(guān)聯(lián)的細(xì)胞分子生物學(xué)特征（Cell Reports Medicine 2023, PMID: 37586321; Cancer Cell 2023，PMID: 37738975；Blood Advances 2023, PMID: 37389847; Nature Medicine 2020, PMID: 33020644）。
3. 鑒定不同類型B細(xì)胞淋巴瘤的免疫微環(huán)境特征，尤其是發(fā)現(xiàn)了與CD19 CAR-T細(xì)胞治療后復(fù)發(fā)、腫瘤細(xì)胞突變和抗原呈遞等相關(guān)聯(lián)的生物學(xué)特征（Cancer Cell, Under Review; Blood Cancer Discovery 2022, PMID: 35687817）。
二、崗位信息
01博士后
1）崗位職責(zé)
1.在PI指導(dǎo)下獨(dú)立開展課題研究；
2.協(xié)助指導(dǎo)實(shí)驗(yàn)室其他成員開展科研工作；
3.撰寫論文或申請基金。
2）任職要求
1.具有生命科學(xué)或其他相關(guān)生物醫(yī)學(xué)領(lǐng)域的研究背景，即將獲得或近期已獲得博士學(xué)位（原則上不超過2年）；
2.以（共同）第一作者身份在領(lǐng)域內(nèi)主流期刊上發(fā)表過或即將發(fā)表研究論文，能夠獨(dú)立開展研究工作，具有科研熱情和嚴(yán)謹(jǐn)?shù)目蒲袘B(tài)度；
3.有免疫學(xué)、小鼠模型實(shí)驗(yàn)或多組學(xué)數(shù)據(jù)分析等研究經(jīng)驗(yàn)者優(yōu)先；
4.精通英語閱讀、寫作和日常溝通，能夠使用英語撰寫論文。
02科研助理
1）崗位職責(zé)
1.獨(dú)立或協(xié)助團(tuán)隊(duì)開展課題研究；
2.管理和維護(hù)實(shí)驗(yàn)室日常工作和行政事務(wù)。
2）任職要求
1.具有生物學(xué)、基礎(chǔ)醫(yī)學(xué)、藥學(xué)等相關(guān)專業(yè)的本科及以上學(xué)位；
2.掌握常規(guī)分子克隆、生物化學(xué)、細(xì)胞培養(yǎng)的操作及原理，有實(shí)驗(yàn)室研究工作經(jīng)歷優(yōu)先；
3.有較強(qiáng)的主觀能動性，具備良好的溝通能力和團(tuán)隊(duì)協(xié)作能力；
4.具備良好的英語讀寫和日常交流能力，能夠使用英文撰寫論文。
三、福利待遇
1.根據(jù)應(yīng)聘者的工作經(jīng)驗(yàn)和能力，提供具有市場競爭力的薪酬（詳情面談）；
2.享受五險(xiǎn)一金、帶薪年假、體檢和補(bǔ)充醫(yī)療保險(xiǎn)等；
3.支持個(gè)人職業(yè)發(fā)展，提供必要的工作相關(guān)專業(yè)培訓(xùn)。
四、申請方法
請將簡歷、個(gè)人陳述（1頁）、至少2名推薦人的基本信息和聯(lián)系方式、工作總結(jié)與研究興趣（1-2頁，僅限博士后），合并為PDF文件發(fā)送至qdeng@cimrbj.ac.cn，請【點(diǎn)擊下方“立即投遞/投遞簡歷”，即刻進(jìn)行職位報(bào)名】，并在郵件主題中注明：“應(yīng)聘博士后/科研助理+本人姓名”，初審?fù)ㄟ^的申請者將會盡快安排面試。
聯(lián)系人：鄧慶
聯(lián)系地址：北京市豐臺區(qū)右安門外西頭條10號-首都醫(yī)學(xué)科學(xué)創(chuàng)新中心
本招聘長期有效，至招聘到合適人選為止。
ABOUT CIMR
Chinese Institutes for Medical Research (CIMR) is a newly founded institution dedicated to fundamental and translational medical research. The CIMR is located at the main campus of the Capital Medical University, Beijing, China and committed to building a scientist-centered governance framework and fostering a diverse and inclusive work environment. For more information, please visit our website: www.cimrbj.ac.cn
Laboratory Introduction
The Deng Laboratory at CIMR has open positions for postdoctoral fellows and research assistants. The laboratory primarily utilizes deep immunophenotyping, single-cell and spatial multi-omics platforms, cell & molecular biology techniques, as well as genetic animal models to investigate the role of B cell heterogeneity in tumor development, metastasis and immunotherapy response. The goal is to gain a deeper understanding of the pathological mechanism of B cells in tumorigenesis and autoimmune diseases, and to further explore potential therapeutic strategies for reprogramming B cell fate. Dr. Deng graduated from the School of Life Sciences of Soochow University and received his doctorate degree from Shanghai Jiao Tong University School of Medicine. Dr. Deng has worked as postdoctoral researcher at internationally renowned research institutions, such as Chinese National Human Genome Center at Shanghai, Baylor College of Medicine and the University of Texas MD Anderson Cancer Center. Dr. Deng has been a CIMR faculty member since March 2025.
Major Research Projects
Characterizing B lymphocytes and tertiary lymphoid structures (TLSs) in the tumor microenvironment, gaining insights into the pathological mechanisms of molecular biological events that regulates B cell fate in tumorigenesis and autoimmune diseases, and providing potential therapeutic strategies.
a. Molecular mechanisms regulating the germinal center-dependent / independent responses of tumor-infiltrating B cells.
b. Mechanisms of B cell maturation and selection in tertiary lymphoid structures.
c. Identification of molecular targets that reprogram B cell fate.
Major Academic Achievements
a. Uncovered mutated genes of SWI/SNF chromatin remodeling complex and its molecular mechanisms regulating on malignant characteristics and fate determination of tumor cells (Cancer Cell 2024, PMID: 38458188 & PMID: 38458187; Nature Genetics 2012, PMID: 22922871).
b. Identified cellular / molecular features that associated with efficacy and toxicity of CD19 CAR-T cell therapy in relapsed or refractory large B-cell lymphoma (Cell Reports Medicine 2023, PMID: 37586321; Cancer Cell 2023, PMID: 37738975; Blood Advances 2023, PMID: 37389847; Nature Medicine 2020, PMID: 33020644).
c. Characterized tumor microenvironment of different subtypes of B-cell lymphoma, specifically found biological features associated with CD19 CAR-T cell therapy, tumor cell mutation, and antigen presentation (Cancer Cell, Under Review; Blood Cancer Discovery 2022, PMID: 35687817).
Open Positions
Postdoctoral Researcher
Main Responsibilities
a. Independently conduct research projects under the guidance of the PI.
b. Mentor junior lab members to carry out experiments.
c. Write manuscripts and grant proposals.
Qualifications
a. Background in life sciences or biomedical fields. Either about to obtain a Ph.D. or recently obtained a Ph.D. degree (preferably within the past 2 years).
b. Published or submitted research papers as (co-) first author in reputable journals in the field, with motivation and ability to independently carry out research work.
c. Research experiences in immunology, mouse model, multi-omics data analysis are preferred.
d. Proficient in English reading, writing and daily communication.
Research Assistant
Main Responsibilities
a. Conducting research projects independently or in collaboration with other lab members.
b. Getting involved in lab management and maintenance.
Qualifications
a. B.S. or higher degree in biology, medicine, pharmacy and other related majors is required.
b. Research experience in molecular biology, biochemistry, cell biology is preferred.
c. Self-motivated researcher with good communication skill and teamwork ability.
d. Proficient in English reading, writing, and daily communication.
Welfare Treatment
a. Provide competitive salary based on the applicant’s work experience and ability (salary negotiable).
b. Provide social insurance and housing fund, supplementary medical insurance, physical examination and paid annual leave.
c. Support career development, provide relevant professional guidance.
How to apply
Please combine your CV, one-page personal statement, contact information of no less than two referees and a 1-2 page research summary and interests (for postdoc applicant only), as well as other materials demonstrating research capabilities into a single PDF file. Send it to qdeng@cimrbj.ac.cn, and indicate “Postdoc/Research Assistant + Your Name” in the email subject. Application review will begin on a rolling basis and qualified applicants will be invited for interview.
Contact person: Dr. Qing Deng
This recruitment is valid for the long term until a suitable candidate is recruited.
信息來源于網(wǎng)絡(luò)，如有變更請以原發(fā)布者為準(zhǔn)。
來源鏈接：
https://mp.weixin.qq.com/s/po6QtbZxC6PKMtWRciyQVw
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